The unspoken attraction between Mulder and Scully formed the backbone of The X-Files.

And David Duchovny and Gillian Anderson proved they still have that chemistry as they met up again to celebrate their iconic show's 20 year anniversary at Comic Con in San Diego, California on Thursday.

The pair reunited to meet fans at a special panel at the show, and soon delighted the crowd when they hinted that we might not have seen the last of their much-loved characters.

Questioned about the possibility of following in the footsteps of 24 with a limited return to the small screen, Anderson said simply that she would not be interested.

But to a roar of audience approval, she then added that 'a film would be great.'

David, 52, and Gillian, 44, broke ground two decades ago in the television series The X-Files and it's two film sequels The X-Files and The X-Files: I Want To Believe.

The hunky David portrayed FBI Special Agent Mulder while Gillian played his disbelieving sidekick Special Agent Scully.

And the status of the pair's relationship has always kept fans guessing, with many hoping they would develop a romance.

Asked by an audience member during the Comic-Con panel would Mulder and Scully would do if they went on a date, Gillian was quick to reply: 'Have sex!'

A slightly more reserved David added: 'And maybe dinner?'

Meanwhile, The X-Files creator Chris Carter added during the panel discussion that the show has only recently become relevant again.

He explained: 'The suspicion and conspiracy theories are so much more rampant today. You could do the show now.

'You couldn’t really do the show in 2002 because people trusted the government — or wanted to. We went through a period there where The X-Files was not relevant.'

Following the panel discussion, Gillian took to the stage to auction off a signed cardboard cutout of herself and David as Mulder and Scully.

For the event, David had that cool Malibu surfer dude look about him, in a white shirt and grey trousers.

And Gillian was elegant in a black sleeveless number that featured a sexy sheer panel in the front.

Although Gillian was a redhead during most of the popular TV show, on this occasion she sported lighter strawberry-blonde locks that were feathered away from her fair-skinned face.

Gillian has paved a singular path in such dramas as The House Of Mirth, Bleak House and most recently starred in BBC crime drama The Fall.

In a recent interview, Gillian said that her role of Stella in The Fall was the closest to how she is in real life.

'Stella is probably one of my favourite characters. I feel like Stella is closer to me than anybody I've played before,' Gillian told OK! Magazine.

When she's not working, Gillian enjoys playing mother to her brood of three children, daughter Piper, 18, from her former marriage to art director Clyde Klotz, and sons Oscar, six, and Felix, four, from her previous relationship with Mark Griffiths.